منابع مشابه
Cytogenetic and molecular analysis in Philadelphia negative CML.
We studied the clinical, hematologic, cytogenetic and molecular biologic features in four patients with Philadelphia (Ph) negative chronic myeloid leukemia (CML). In all four cases the clinical and hematologic characteristics were indistinguishable from Ph positive CML. Cytogenetic analysis showed a normal karyotype in two patients and chromosomal translocations apparently not affecting chromos...
متن کاملClinical implications of cytogenetic variants in chronic myelocytic leukemia (CML).
By JACQUELINE WHANG-PENG, GEORGE P. CANELLOS, PAUL P. CARBONE AND J. H. Tjio T HE Ph’ CHROMOSOME, with the exception of a few cases of acute leukemia,’5 occurs only in patients with chronic myelocytic leukemia and is still the only consistent chromosome abnormality found in neoplastic diseases.4’9 In about 85 per cent of patients with CML, the Ph1 chromosome is found in most if not all marrow c...
متن کاملCytogenetic alterations in CML: not all created equal
The prognosis of patients with chronic myeloid leukemia (CML) has dramatically improved since the general availability of tyrosine kinase inhibitors (TKIs). Although uncommon, progression to blast phase (BP) remains a major concern in the management of patients with CML given the lack of effective treatment for and dismal outcome associated with BP. This necessitates the early identification of...
متن کاملImpact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV.
The prognostic relevance of additional cytogenetic findings at diagnosis of chronic myeloid leukemia (CML) is unclear. The impact of additional cytogenetic findings at diagnosis on time to complete cytogenetic (CCR) and major molecular remission (MMR) and progression-free (PFS) and overall survival (OS) was analyzed using data from 1151 Philadelphia chromosome-positive (Ph(+)) CML patients rand...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV
*Alice Fabarius,1 *Armin Leitner,1 Andreas Hochhaus,2 Martin C. Müller,1 Benjamin Hanfstein,1 Claudia Haferlach,3 Gudrun Göhring,4 Brigitte Schlegelberger,4 Martine Jotterand,5 Andreas Reiter,1 Susanne Jung-Munkwitz,1 Ulrike Proetel,1 Juliana Schwaab,1 Wolf-Karsten Hofmann,1 Jörg Schubert,6 Hermann Einsele,7 Anthony D. Ho,8 Christiane Falge,9 Lothar Kanz,10 Andreas Neubauer,11 Michael Kneba,12 ...
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ژورنال
عنوان ژورنال: The Indian Journal of Medical Research
سال: 2012
ISSN: 0971-5916
DOI: 10.4103/0971-5916.93418